Characterization of Ribavirin Aerosol With Small Particle Aerosol Generator and Vibrating Mesh Micropump Aerosol Technologies.

نویسندگان

  • Brian K Walsh
  • Peter Betit
  • James B Fink
  • Luis M Pereira
  • John Arnold
چکیده

BACKGROUND Ribavirin is an antiviral drug that can be administered by inhalation. Despite advancements in the oral delivery of this medication, there has been a renewed interested in delivering ribavirin via the pulmonary system. Although data are not conclusive that inhaled ribavirin improves outcomes, we set out to determine whether delivery by a newer generation nebulizer, the vibrating mesh micropump, was as effective as the recommended small-particle aerosol generator system. METHODS We compared the physicochemical makeup and concentrations of ribavirin before and after nebulization with 0.9% NaCl and sterile water. An Andersen cascade impactor was used to determine particle size distribution and mass median aerodynamic diameter, and an absolute filter was used to measure total aerosol emitted output and inhaled dose during mechanical ventilation and spontaneous breathing. Ribavirin was analyzed and quantified using high-performance liquid chromatography with tandem mass spectrometric detection. RESULTS Ribavirin was found to be stable in both 0.9% aqueous NaCl and sterile water with an r(2) value of 0.96 and identical coefficients of variation with no difference in drug concentration before and after nebulization with the vibrating mesh micropump. The small-particle aerosol generator produced a smaller mass median aerodynamic diameter (1.84 μm) than the vibrating mesh micropump (3.63 μm, P = .02); however, there was no significant difference in the proportion of drug mass in the 0.7-4.7-μm particle range. Total drug delivery was similar with the small-particle aerosol generator and vibrating mesh micropump in both spontaneously breathing (P = .77) and mechanical ventilation (P = .48) models. CONCLUSIONS The vibrating mesh micropump nebulizer may provide an effective alternative to the small-particle aerosol generator in administration of ribavirin using NaCl or sterile water, both on and off the ventilator. Further clinical studies are needed to compare efficacy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An Ethanol-Based Proliposome Technology for Enhanced Delivery and Improved “Respirability” of Antiasthma Aerosols Generated Using a Micropump Vibrating-Mesh Nebulizer

Salbutamol sulphate liposomes were generated using ethanolbased proliposomes followed by nebulization using an Aeroneb Pro vibrating-mesh nebulizer. The droplet size, output and fine particle fraction (FPF) of the drug incorporated in liposome formulation were compared to those of a conventional drug solution. Aerosol output was determined gravimetrically and drug output was analyzed by using h...

متن کامل

Transnasal Aerosol Delivery to Pediatric Patients: Jet Versus Vibrating Mesh--Reply.

To the Editor: In the recent paper by El Taoum and associates,1 an in vitro comparison of aerosol dose delivery using jet and vibrating mesh nebulizers with a variety of nasal interface devices in pediatric patient models was presented. The results of this study demonstrated that the jet nebulizer was more efficient than the vibrating mesh nebulizer across all of the nasal interface devices tes...

متن کامل

Development, Operation and Applications of an Aerosol Generation, Calibration and Research Facility

An aerosol generation, calibration, and research facility has been developed with the major purpose of evaluating aerosol instrumentation, including quality assurance testing, intercomparison, performance evaluation, and calibration of aerosol sizing, bulk, and speciated mass-measuring instruments. The aerosol facility also provides excellent opportunities for basic aerosol research. Polydisper...

متن کامل

Experimental Study of Charging Efficiencies and Losses of Submicron Aerosol Particles in a Cylindrical Tri-Axial Charger

The object of the present work was to design, construct and evaluate a cylindrical tri-axial charger for charging of submicron aerosol particles by unipolar ions. The corona discharge characteristics, the intrinsic and extrinsic particle charging efficiencies, and the losses of aerosol particles were experimentally evaluated for particle diameters in the range between 50 nm and 500 nm under dif...

متن کامل

Design and Construction of an Aerosol Particle Classification System Based on Electrical Mobility

Introduction: The application of particles’ electrical mobility in the electric field has always been an important concern, as the functional basis of a number of particle measuring and classification instrumentations. The objective of this study was to design and construct an aerosol particles classification system using electrical mobility feature in laboratory scale. Methodology: This labo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Respiratory care

دوره 61 5  شماره 

صفحات  -

تاریخ انتشار 2016